If you are planning on setting CloudPanel to use Basic Authentication (recommended) instead of Kerberos when calling powershell commands on Exchange then you must enable Basic Authentication on the powershell virtual directory. You only need to do this on the Exchange server you are configuring CloudPanel to communicate with.

Also make sure you are enabling basic authentication using ECP / EAC and not directly on IIS.

Sometimes new updates to Exchange can cause this setting to reset.