Connecting to remote server failed with the following error message : The WinRM client sent a request to an HTTP server and got a response saying the requested HTTP URL was not available. This is usually returned by a HTTP server that does not support the WS-Management protocol. For more information, see the about_Remote_Troubleshooting Help topic.
When you apply updates to Microsoft Exchange it will most like reset the Basic Authentication setting on the Powershell virtual directory. You will need to go back into EAC and enable this again.
The IIS website CloudPanel is using is not running under an application pool that is running as a domain user that has rights to Microsoft Exchange. Please verify that CloudPanel is running under the correct application pool.